Numerical calculation of bone strength in rats exposed to impaired motor activity
Oleg V. Gerasimov1, Nikita G. Iskakov1, Anton A. Eremeev2, Maxim E. Baltin1, Arthur O. Fedyanin1; 1Volga Region State University of Physical Culture, Sport and Tourism, Kazan, Russia; 2Kazan Federal University, Kazan, Russia
Abstract
Remodeling of bone and muscle tissue determines pathophysiological mechanisms leading to the development of osteosarcopenia. The work considers bones of rats subjected to antiorthostatic suspension. The experimental protocol was approved by the Local Ethics Committee of the Volga Region State University of Physical Culture, Sport and Tourism. The experiments involved: antiorthostatic suspension with electrical stimulation of the spinal cord, antiorthostatic suspension with readaptation and electrical stimulation of the spinal cord.
The obtained results reflect the effect of electrical stimulation of the spinal cord on ultimate stresses. Readaptation reduces the deviation of the results relative to the control group data. The elastic modulus increases for the forelimbs and decreases for the hind limbs. Sexual separation of the samples showed an insignificant effect of ultimate stresses for young individuals and a significant effect for old ones. The elastic modulus has a significant deviation for both young and old animals.
The research was funded by a grant from the Russian Science Foundation and the Academy of Sciences of the Republic of Tatarstan under project No. 23-25-10065.
Speaker
Oleg Gerasimov
Volga Region State University of Physical Culture, Sport and Tourism
Russia
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