On the mesh structures of an intramedullary rod
Igor A. Bespalov1, Nikita V. Kharin1, Pavel V. Bolshakov1,2, Rashid A. Shafigulin3, Oskar A.Sachenkov1; 1Kazan Federal University, Kazan,Russia;
2Department Machines Science and Engineering Graphics, Tupolev Kazan National Research Technical University, Kazan, Russia
3Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
Abstract
There are various technical solutions for the delivery of various drugs using intramedullary implants. For example, a mantle of bone cement containing various antibiotics is intraoperatively applied to the surface of the intramedullary implant, which subsequently elutes from the bone cement into the environment. This solution with clinical efficiency has disadvantages, which consist in the reduced adhesion of the bone cement on the implant surface due to the smooth structure of the latter, because of which the cement mantle can remain in the medullary canal when the implant is removed. A separate disadvantage is the small volume of bone cement in the pathologic focus area. This, as a consequence, leads to a shorter duration of elution.
The lattice structure, which is designed to provide the required strength, must have a large free volume, which is filled with the drug. Localization of the implant zone replaced by the lattice structure is determined by the localization of the pathological focus in the organ individually. The geometry of the lattice structure is determined from the condition of maximizing the free volume to accommodate the maximum amount of drug and maintaining the required strength and rigidity of the structure.
The paper presents numerical and in situ experiments on bending stiffness and strength of three types of structures. The in vitro antibiotic release volume for the designed structures was evaluated.
This research was funded by the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities, project No. FZSM-2023-0009.
Speaker
Pavel Bolshakov
Kazan Federal University
Russia
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