Compact sapphire probe for sensing tissue properties during microcirculation disorder
Alina A. Platonova1, Polina V. Aleksandrova1, Anna I. Alekseeva2, Sophya P. Kudryavtseva3, Arsen K. Zotov1,4, Kirill I. Zaytsev1, Kirill B. Dolganov1, Vladimir N. Kurlov4, Irina N. Dolganova4; 1 – Prokhorov General Physics Institute RAS, Moscow, Russia,
2 – Avtsyn Research Institute of Human Morphology, Moscow, Russia,
3 – Sklifosovskiy Institute of Clinical Medicine, Sechenov University, Moscow, Russia,
4 – Osipyan Institute of Solid State Physics RAS, Chernogolovka, Russia
Abstract
The occurrence of such surgical consequences as tissue hypoxia, ischemia and associated necrosis is highly undesirable in clinical practice. Therefore, for the modern medicine, one of the urgent problems is to promptly detect microcirculation disorder. To deal with this issue, we propose a compact sapphire fiber-based probe with optical sensing, which performs of spatially resolved diffuse reflectance (SRDR) analysis of intensity of back scattered light.
Such method enables for intraoperative measurement of tissue effective attenuation coefficient and its alteration aimed at the estimation of tissue condition that changes during the microcirculation disorder. When using SRDR technique for the measurement, fibers should be fixed at certain positions and the material of the probe should meet several demands, for this reason we proposed sapphire to be used as a material and the edge-defined film-fed growth (EFG) technique for manufacturing inflexible probe and connect it with optical fibers.
To test the feasibility of the proposed probe, we perform two cases imitating the microcirculation disorder: 1 – a tissue-mimicking phantom consisted of lipid emulsion and hemoglobin, which changes its properties during adding enzyme; 2 – model of hindlimb ischemia carried out in rats. The alteration of attenuation coefficient observed in these cases demonstrated the opportunity to detect rapid changes of tissue properties confirming the viability of the probe to sense the stressful exposure. Due to a compact design of the probe, it could be used as an auxiliary instrument for rather wide range of surgical operations and diagnostic purposes.
This work was supported by a grant of the Ministry of Science and Higher Education of the Russian Federation (075-15- 2022-315) for the organization and development of a World-class research center "Photonics"
Speaker
Alina A. Platonova
Prokhorov General Physics Institute of the Russian Academy of Science, Moscow, Russia
Russia
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