The importance of functional dyes in advancing nanobiochemical pharmacology and toxicology

Abstract

Aggregation-induced emission luminogens (AIEgens) represent a unique class of luminescent materials exhibiting enhanced emission upon aggregation, unlike conventional fluorophores prone to quenching. This property minimizes background fluorescence and enables robust emission in the aggregated state, making them highly desirable for bioimaging and organic optoelectronic devices. The ongoing development of AIEgens with precisely controlled properties holds particular promise for nanomedicine research. By incorporating AIEgens into nanoparticles, researchers can gain valuable insights into particle biodistribution, cellular trafficking, and degradation in biological systems, ultimately contributing to advancements in nanoparticle design and understanding their impact on living organisms. This presentation will showcase the use of AIEgens in novel albumin nanoparticles designed for endosomal degradation and track microplastic fate in liver cells and zebrafish models.
This work was supported by Russian Science Foundation Grant# 21-75-30020

Speaker

Alessandro Parodi
Leading Scientist Sirius University of Science and Technology Department of Translational Medicine Laboratory of Molecular Nanomedicine
Russian Federation

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