Diffuse optical spectroscopy for investigation of biological tissues
Ilya V. Turchin1; 1Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia
Abstract
Diffuse optical spectroscopy (DOS) is a non-invasive technique for examination of biological tissues by probing them with light at multiple wavelengths and detecting backscattered or propagated light at a given distance from the light source. The detected diffuse light carries information on attenuation of light in tissue, that is defined by the reduced scattering and absorption coefficients. The reduced scattering of biological tissues is usually represented with a monotonously decaying function with the wavelengths while absorption spectra of different chromophores (oxyhemoglobin, deoxyhemoglobin, lipid, water, melanin, etc.) have more sophisticated shapes, that allows one to reconstruct chromophores composition from the registered extinction spectrum. Chromophore composition provides information on tissue functional state from blood and water content, blood oxygen saturation that can be applied for investigation of brain function, diagnostics of different skin and mucosae diseases, breast cancer and other pathologies. The accuracy of reconstruction procedure of a component composition depends on two key factors: 1) accuracy of extinction spectrum measurements and 2) accuracy of the model of light transport in tissue. Both factors will be discussed in the presentation.
Speaker
Ilya Turchin
Institute of Applied Physics of the Russian Academy of Sciences
Russia
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