Derivatives of BODIPY dye for bioimaging and therapy
Alexey A. Pakhomov; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia
Abstract
Derivatives of the fluorescent dye BODIPY are currently actively applied in bioimaging and biosensing, as well as in photodynamic and photothermal therapies. In this talk, we present some of our recent progress in the synthesis and application of BODIPY for the study of living systems and theranostics. For example, lipophilic derivatives of BODIPY accumulate in membrane structures due to their high hydrophobicity and allow to use them as cell contrasting agents in microscopic and cytometric protocols. Multichromophore compounds deserve special attention, since they have unusual optical properties and can be used to monitor cell membrane parameters, for effective two-photon excitation, and for sensing reactive oxygen species. We also synthesized water-soluble derivatives of BODIPY and developed protocols for their conjugation to biomolecules and subsequent visualization in cellular experiments. We also obtained iodine derivatives of BODIPY, which have exceptionally high photosensitization activity compared to other organic and protein photosensitizers, especially in the form of targeted phototoxins. These features open wide horizons for further application of the obtained BODIPY-based photosensitizers for photodynamic therapy.
Speaker
Alexey A. Pakhomov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russia
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