Spectral studies of the structure of regioisomeric pyridyl substituted aminochromencarbonitriles and their iodomethylanes
Alexandr V. Nikulin, 1, Adele P. Kriven'ko, 1 1 Saratov State University, Saratov, Russia
Abstract
Using one-dimensional (1H, 13C) and two-dimensional (HSQC, HMBC) spectroscopy, the structure and ratio of isomers of 4,8-C-substituted phenyl (phenylmethylidene), pyridyl (pyridylmethylidene) aminochromencarbonitriles were established. Individual isomers obtained by separating their mixture using column liquid chromatography are characterized spectrally. Using the NMR spectra of 1H, HSQC and HMBC, it was found that the iodomethylation of the obtained aminochromencarbonitriles proceeds selectively with the participation of the nitrogen atom of the pyridine fragment with the formation of the corresponding water-soluble mono-, diiodmethylates. Among the new substances obtained, compounds exhibiting antibacterial activity were isolated.
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Alexandr V. Nikulin
Saratov State University
Russia, Saratov
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