Measurement of the refractive index of the different animals' head tissues using OCT and multi-wavelength refractometer: Comparative study
Alaa S. SHanshool1, E. N. Lazareva1,2, D. K. Tuchina1,2, E. A. Genina1,2, V. V. Tuchin1,2; 1Saratov National Research State University named after N.G. Chernyshevsky, Saratov, Russia, 2National Research Tomsk State University, Tomsk, Russia.
Abstract
Accurately measuring RI is essential to provide high-fidelity optical images since RI is a key parameter for image reconstruction and interpretation as well as for understanding light-tissue interactions. In addition, clinical diagnosis can be made based on RI differences between normal and malignant tissues. This study focuses on the measurements of the refractive index of the rat head tissue samples (scalp, skull, dura mater, gray and white matter) and the cow's brain tissue samples (dura mater, gray and white matter) and compare them, ex vivo in the visible/NIR spectral range at room temperature. Measurements were performed using OCT (930 nm) and the multi-wavelength Abbe refractometer for characteristic laser wavelengths: 480, 486, 546, 589, 644, 656, 680, 800, 930, 1100, 1300, and 1550 nm. The coefficients of the Sellmeier formula were calculated for the approximation of tissue dispersion.
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Alaa Sabeeh Shanshool
Saratov University
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