Assessment of the group variability of the parameters of the microcirculatory-tissue system by using multimodal wearable device
Viktorya E. Parshakova, Yulia I. Loktionova, Elena V. Zharkikh, Andrey V. Dunaev
Research and Development Center of Biomedical Photonics, Orel State University, Orel, Russia
Abstract
The parameters of the microcirculatory-tissue systems (MTS) of the human body are subject to changes, the use of functional tests allows to improve the diagnosis of the MTS condition by laser Doppler flowmetry (LDF) and fluorescence spectroscopy (FS). The aim of the study was to evaluate the group variability of the parameters of the MTS in healthy volunteers during basal measurements and occlusion tests with the use of the wearable device.
The study involved healthy volunteers (2 men and 3 women) aged 21±1 years. MTS parameters were recorded using 4 wearable analyzers "LAZMA PF". One measurement consisted of 2 tests: baseline measurement and a brachial artery occlusion (OT).
The data obtained demonstrates that the values of the index of microcirculation (Im) differ in different measurement areas due to the anatomical features of the skin. The greatest coefficient of variation of Im in men was observed on the toes and fingers, in women – on the toes and on the forehead. The blood flow reserve (BFR) was 179.3±5.0% for men, 138.7±30.2% for women. The coefficient of variation of BFR in men was 21.8±11.6%, in women 12.5±8.0%.
As a result, the values of group variability were obtained in men and women for tissue perfusion with blood, which averaged about 30%. The values of the coefficient of variation of the BFR measured by wearable devices were mainly 22%, which is comparable to the results obtained on a stationary device (mainly 23%).
This work was supported by the Russian Science Foundation under Project No. 23-25-00522.
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Viktorya Parshakova
Research & Development Center of Biomedical Photonics, Orel State University, Orel
Russia
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