Compression optical coherent elastography for detecting microruptures of the intestinal wall during tissue distraction
Elena B. Kiseleva,1 Alexander A. Sovetsky,2 Anton A. Plekhanov, 1 Maxim G. Ryabkov,1 Ekaterina V. Gubarkova,1 Evgeniya L. Bederina, 1 Natalia D. Gladkova, 1 Vladimir Y. Zaitsev,2 1 Privolzhsky Research Medical University, Nizhny Novgorod, Russia 2 Institute of Applied Physics of the RAS, Nizhny Novgorod, Russia
Abstract
Having sufficient resolution (about 40-50 µm) and high sensitivity to changes in tissue elasticity, the method of compression optical coherence elastography (C-OCE) can become a key objective tool in solving the problem of controlling distraction-induced intestinal enterogenesis in patients with short bowel syndrome. The results of our study showed that when the samples of the intestinal wall of minipigs were stretched by more than 40% of the initial length, a significant drop in tissue stiffness was recorded using C-OCE, due to the resulting microruptures. Numerous ruptures in the muscular membrane are fixed on the stiffness maps when the tissue is elongated by 38-45% of the original length. The mucous membrane is more resistant to longitudinal stretching: local ruptures occur when the tissue is elongated by 50-55% of its original length.
Speaker
Elena Kiseleva
Privolzhsky Research Medical University
Россия
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