Modelling of the process of formation of a laser welded seam of biological tissue under irradiation by laser radiation with dynamically changing focal distance
D. I. Ryabkin 1,2, V. V. Suchkova 1,2, A. Yu. Gerasimenko1,2
1 I.M. Sechenov First Moscow State Medical University, Moscow, Russia;
2 National Research University of Electronic Technology MIET, Zelenograd, Moscow, Russia;
Abstract
Laser welding is a promising alternative method of joining dissected biological tissues to traditional methods of joining with sutures, adhesives, etc. The main limitation to the widespread application of laser welding of biological tissues in surgical practice is the formation of the area of thermal necrosis of the joined tissues and insufficient depth of suture formation. Traditionally, laser welding of biological tissues has used either collimated or constant focal length radiation. In this work we have modelled the process of laser weld formation using laser radiation with a variable focal length and directed at an angle in the plane of weld formation.
The model of laser weld formation has been developed for welding different biological tissues and using special solders. A solder based on bovine serum albumin, carbon nanotubes and indocyanine green chromophore was used. The model calculates heat transfer, the degree of protein denaturation as a function of temperature and laser exposure time, and the spatial distribution of absorbed laser energy.
By using laser radiation with a variable focal distance, the heating of biological tissues could be reduced and the area of thermal necrosis formation could be reduced by more than 80%. Varying the focal distance in the suture formation process allows to form sutures more than 2 times deeper compared to the use of collimated radiation.
The study was supported by the Russian Science Foundation grant No. 22-75-00089,
https://rscf.ru/project/22-75-00089/
Speaker
Dmitrii Rybkin
I.M. Sechenov First Moscow State Medical University
Russia
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