Study of the effect of detonation nanodiamond on microfungi
E. Perevedentseva1), V. Sychev1), E. Kuzmin1), S. Savinov1), T. Limonova1), S. V. Sadykova2), A. Kuvarina2), O. Streletskiy3), N. Melnik1)
1) P. N. Lebedev Physical Institute of Rus Acad Sci, Moscow, Russia
2) Laboratory of Taxonomic Study and Collection of Cultures of Microorganisms, Gause Institute of New Antibiotics, Moscow, Russia
3) Faculty of Physics, M.V. Lomonosov Moscow State University, Moscow, Russia
Abstract
The antimicrobial properties of nanostructures are currently considered for using as an alternative to antibiotics. For detonation nanodiamonds (DND) destructive effect on some pathogenic microorganisms was observed previously [1]. While antibacterial effect was demonstrated for number of both gram-negative and gram-positive bacteria, mechanisms are discussed, and prospective applications are suggested, for microscopic fungi it is practically not investigated yet.
In the presented work the effect of ultradispersed nanodiamonds on some strains of conditionally pathogenic fungi is analyzed.
A prominent inhibition effect was observed for fungi of the genus Aspergillus – A. niger, A. fumigatus and yeast Candida albicans using diffusion-in-agar test. This allows considering the use of DND for the development of antifungal agents and coatings. Raman/autofluorescence spectra measured at various excitations and SEM images provide the information for discussion of structural changes occur in the fungi cell wall under the DND particles influence.
[1] Streletskiy et al, Magnetochemistry. 2022, 8(12), 171;
https://doi.org/10.3390/magnetochemistry8120171
Speaker
Elena Perevedentseva
P.N. Lebedev Physical Institute Rus. Acad. Sci.
Russia
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