Hydrogel-Supported Microchambers for Modulation of Oxidative Stress During Wound Healing
Ermakov A.V.1,2, Savkina A.A.1, Stepanova T.A.1, Lengert E.V.1,2, Sukhorukov G.B.3, Ivanov A.N.1
1 Central Research Laboratory, Saratov State Medical University of V. I. Razumovsky, Ministry of Health of the Russian Federation, 410012 Saratov, Russia
2 Institute of Molecular Theranostics, I. M. Sechenov First Moscow State Medical University, 8 Trubetskaya Str., 119991 Moscow, Russia
3 Skolkovo Institute of Science and Technology, 3 Nobelya Str., Moscow 143025, Russia
Abstract
Rapid wound healing requires maintaining an optimal chemical environment to stimulate the body's mechanisms for tissue regeneration. Hydrogel-based wound dressings have shown great promise in promoting wound healing due to their unique properties, such as high water content, biocompatibility, and ability to maintain a moist environment. However, current hydrogel dressings have limitations, such as poor mechanical strength, rapid dehydration, and inadequate drug delivery capabilities. Drug delivery profiles of hydrogel dressings tend to exhibit burst release of active substances into wound. Operation with reactive oxygen species represent an important and challenging task, since optimal and controllable oxidative stress is neccessery to suppress inflammatory, but enable rapid proliferation of fibroblasts and their functions without crucial irritating effect. In this regard, control over levels of ROS and antioxidants seems to be one of the key tasks to improve wound healing process. Here we introduce novel platform to serve as a wound dressing based on hydrogel and array of microchambers. Thus we develop a new platform to maintain chemical triggers and release of bioactive substances.
The work was carried out within the framework of the state task of the Saratov State Medical University named after V.I. Razumovsky” of the Ministry of Health of Russia “Development of microchamber wound dressings providing local modulation of tissue oxidative homeostasis” (registration number 122031600259-9).
Speaker
Alexey V. Ermakov
Institute of Molecular Theranostics, I. M. Sechenov First Moscow State Medical University
Russia
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