Nanoparticles against tumors: anticancer drugs for use in silica-based drug delivery systems.

Abstract

Anticancer drugs are characterized by a significant set of side effects. In order to minimize these effects, various delivery systems are being actively investigated, which allow to reduce the dosage of the drug. As part of our research, the task was to select the optimal anticancer drugs for loading into silica-based nanocontainers and their subsequent delivery to the tumor tissue. A review of the current literature was carried out, as a result of which the drugs with a maximum in the absorption spectrum and a minimum effective dose were selected. Anticancer drugs represent various groups, including platinum-based drugs, anthracyclines and taxanes. As part of a project to develop drug delivery systems, it was necessary to select drugs from different groups that have high efficacy (i.e., have a low minimum effective dose) and a pronounced peak in the absorption spectrum. By measuring the absorption spectrum, the loading and release of drugs from nanocontainers will be monitored, and the highly effective therapeutic effect of the drug makes it possible to use its minimum effective concentration. As a result of the study, substances that meet the specified requirements within each group were selected. Further research will focus on the use of selected drugs in drug delivery systems.
This work was supported by the Russian Science Foundation (project No. 23-22-00354, https://rscf.ru/en/project/23-22-00354/).

Speaker

Anton Oleinikov
1 – Institute of Biochemistry and Physiology of Plants and Microorganisms – Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), Saratov, Russia; 2 – Saratov Stat
Russia

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