Self-assembled porphyrazine nanoparticles interaction with albumin by dynamic light scattering
Aleksei R. Krot, Irina A. Sergeeva, Ksenya V. Fedorova , Aleksandr I. Ladynin
Department of molecular processes and extreme
states of matter, Faculty of Physics, Lomonosov
Moscow State University, Moscow, Russia
Abstract
The using of nanoparticles as a potential building material for photosensitizers is a subject of increased interest in the field of photodynamic therapy.
The objects of study in this work are porphyrazine-based photosensitizers capable of self-dissolving in water, forming stable nanosized micellar structures and thus providing passive targeting.
Such self-assembled nanoparticles, in addition to a number of advantages in the efficiency of increasing the light intensity absorption and expanding the absorbed light range, are distinguished by the ability to retain therapeutic substances or a passive load, which can be polyvinylpyrrolidone (PVP). It provides a number of important properties for the interaction of nanoparticles with the main proteins of human blood.
The method of dynamic light scattering was used to measure the sizes of nanoparticles and to track the dynamics of potential interaction. As a result of a comparative analysis of self-assembled porphyrazine nanoparticles with and without PVP, properties that make it possible to implement various methods of targeted drug delivery to tumor tissues were measured.
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Speaker
Krot Aleksei Romanovich
MSU Faculty of Physics
Russia
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