Mechanism of oxygen regulation during hypoxia by HIF-1α protein on carboxyl-functionalized MWCNTs
Nadezhda G. Bobenko,1, Vladislav V. Shunaev, 2, Petr M. Korusenko,3, Valeriy E. Egorushkin,1, Olga E. Glukhova, 2; 1 Institute of Strength Physics and Materials Science of SB RAS, Tomsk, Russia, 2 Department of Physics, Saratov State University, 410012 Saratov, Russia, 3 St. Petersburg State University, Universitetskaya embankment, St. Petersburg, Russia
Abstract
Nitrogen-doped multilayer functionalized carbon nanotubes (N-MWСNTs) are widely used for drug delivery. Delivery of the HIF-1α protein is an important task, since its deficiency or excess leads to oncological, cardiovascular and other diseases. To determine the efficiency N-MWСNTs were synthesized by catalytic chemical vapor deposition and functionalized with COOH- after irradiation with argon ions. Detailed information about the chemical state, local structure of the material, types of structural defects (formation of crystallites and Stone-Wales defects) was obtained using Raman spectroscopy, HRTEM, XPS and NEXAFS methods. It has been theoretically shown that the presence of Stone–Wales defects significantly reduces potential barriers and facilitates the attachment of COOH- groups to the surface of nanotubes [1]. The main role in functionalization, diffuse relaxation, oxygen regulation, and the possibility of drug delivery is played by the hybridization of electronic states. The nature of wave diffusion is determined by the hybridization of the protein’s -OH and the O=C from carboxyl group. The most suitable for drug delivery are COOH-N-MWCNTs with 6 at.% oxygen from carboxyl groups.
Speaker
Nadezhda Bobenko
Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS)
Russia
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