pH-Responsive Core-Shell Structures for Controlled Release of Encapsulated Compounds
Kuznetsov A. O.1, Vlasicheva Yu. N.2, Lengert E. V.1, Zvyagin A. V.1, Ermakov A. V.1
1 Institute of Molecular Theranostics, I. M. Sechenov First Moscow State Medical University, 8 Trubetskaya Str., 119991 Moscow, Russia
2 Russian University of Chemical Technology DI. Mendeleev, 9/6 Miusskaya Square, Moscow, 125047 Russia
Abstract
The development of drug delivery systems is a key focus in modern biomedicine. Recent trends have shifted towards complex and multicomponent carriers in order to enhance targeting and selectivity. In this study, we explore the utilization of site-specific properties, such as pH levels, to improve the efficacy of carriers. Specifically, a core-shell structure based on mesoporous particles of calcium carbonate and AMS-6 silica particles is developed. The loading capacity and release kinetics of a model dye, TRITC-BSA, from the complex particles are investigated. The findings indicate that the carriers have potential as drug carriers with pH-dependent release kinetics, opening new possibilities for therapeutic applications.
Funding: The study was supported by the RUSSIAN SCIENTIFIC FOUNDATION, Grant No. 22-73-10032,
https://rscf.ru/project/22-73-10032/ (accessed on 28 July 2022)
Speaker
Alexey V. Ermakov
Institute of Molecular Theranostics, I. M. Sechenov First Moscow State Medical University
Russia
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