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Multimodal characterization of optical properties of urinary stones ex vivo for classification based on hyperspectral imaging, terahertz spectroscopy and integrating sphere measurements: Preliminary results

Walter Blondel1, Mélanie Menneglier1, Clarice Perrin-Mozet1, Hoalian Shi2,
Alexandre Locquet2, Arnaud Marotel3, Marie Camonin1, Christian Daul1,
Béatrice Caillierez4, Jacques Hubert1,4 and Marine Amouroux1

1 Université de Lorraine, CNRS, CRAN UMR 7039, Vandoeuvre-Lès-Nancy, France
2 International Research Laboratory Georgia Tech, CNRS, IRL 2958, Metz, France
3 Ecole Nationale Supérieure de Géologie, Vandoeuvre-Lès-Nancy, France
4 Centre Hospitalier Régionale et Universitaire, CHRU, Vandoeuvre-Lès-Nancy, France


The urolithiasis disease is charactezied by the formation of crystallized hard stone in the urinary system. Among the standard clinical procedure to eliminate these stones, they are fragmented in order to be extracted through natural routes. These fragments are analyzed with a microscope and infrared spectroscopy to determine the biochemical composition of the stones. However, with technological innovation in laser-based treatment of urinary stones, it is more complicated to make these analyses because of the pulverization of the stones. Therefore there is a need for investigating new approaches exploiting optical techniques to identify the stone's nature before pulverization.
The present study aims at exploring the potential of three complementary methods in the optical characterization of urinary stones ex vivo samples, including hyperspectral imaging, double integrating spheres-based optical property measurement and terahertz spectroscopy and imaging.
Preliminary results obtained over a limited number of sample from three different classes of urinary stones will be presented and discussed. They confirm the potential interest and complementary relevance of the different approaches to differentiate the latter groups.

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