Animal anesthesia in long-term experiments on imaging and surgical intervention
Veronika N. Volodina 1, Elizaveta V. Okuneva1, Astemir R. Likhov 1 Victoria V. Zherdeva 1
1 RC of Biotechnology of the RAS, Moscow, Russia, *vjerdeva@inbi.ras.ru;
2 Saratov State University, Saratov, Russia;
3 MIREA — Russian Technological University, Moscow, Russia.
Abstract
The aim of our work was to understand the optimal anesthesia regimen for long-term monitoring in bimodal imaging of experimental animals (laboratory mice), especially when surgery is required.
We were able to select the conditions under which all manipulations were carried out using 1.5-2% isoflurane. We have demonstrated that when using isoflurane anesthesia, the survival rate of animals is about 100% compared with 70% combined anesthesia at the same time of observation.
Adequate selection of anesthesia can reduce the loss of animals during surgery and increase survival during long-term monitoring.
Funding
This research was funding by Ministry of Science and Higher Education of the Russian Federation grant № 13.2251.21.0009 from 29.09.2021 (Agreement № 075-15-2021-942).
Speaker
Veronika Volodina
RC of Biotechnology of the RAS
Russia
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