Dynamic sequence-specific homologies in chromatin: imperfection as a driving force of life.
Ivan Savelev1, Aleksandr Vikhorev1, Nelly Zyryanova1, Oksana Polesskaya1, Richard Alan Miller1, Inna Plastun2, Pavel Zhylidin2, Pavel Filin2, Michael Rempel1, and Max Myakishev-Rempel1, 1DRRF, USA, 2Saratov State Technical University, Russia
Abstract
In this study, we are analyzing the continuous dynamic restructuring of chromatin, a crucial process for comprehending genome signaling. This is a continuation of our research into the interactions between electron and proton chains in DNA structures. The potential influence of these chains on the modulation of properties and dynamics of the genome necessitates the analysis of the DNA's water-ion shell. We are examining the specificity of interactions between the two loops of double-stranded DNA in the nucleosome. The derived structural model was verified using public genomic data, and confirmations of its validity were found. Signs of the presence of the proposed nucleosomal substructure in the evolutionary process were identified. This clarifies the role of chromatin's structural imperfection as a driving force of its dynamics in biological processes.
Speaker
Max Myakishev-Rempel
DRRF, USA
United States
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