The possibilities of using a microstructural waveguide for the analysis of biomaterials.
Pavel A. Lepilin1,2, Anastasia A. Zanishevskaya1,2, Svetlana S. Konnova1,2, Valery Tuchin2, Yulia S. Skibina1,
1 SPE LLC “Nanostructured Glass Technology” Saratov, Russia
2 Institution of Physics and Science Medical Center, Saratov State University, Russia
Abstract
The presented work is devoted to some of the numerous possibilities of using microstructural waveguides as sensor systems for the analysis of biomaterials. A blood plasma study was performed to detect the presence of antibodies to the SARS-CoV-2 (COVID-19) protein using hollow-core MSV and the classical ELISA method. The spectral characteristics of positive and negative samples obtained with the help of MSV were processed using a mathematical algorithm developed by us in the MATLAB program. The main parameters with the greatest differences obtained after mathematical processing are the integral area and intensity. Our study showed that for plasma negative for antibodies to COVID-19 at some wavelengths – 535, 567, 597, 656, 733 nm, both indicators are higher than those of positive samples. Our group also conducts similar studies of food products (wine materials), where MSV has shown its promise for the development of a system for analyzing the quality and origin of wine materials, conducted studies on quantitative and qualitative measurement of blood components (albumin and cholesterol), conducted pilot studies in the analysis of gaseous media and human exhalation.
Speaker
Pavel A. Lepilin, Svetlana S. Konnova
Saratov State University, Saratov, Russia
Russia
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