Optical Imaging and Modulation of Meningeal Lymphatic Vessels
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD). However, how to ameliorate AD by optical imaging and modulation of mLVs remains a great challenge. Based on the superficial spatial distribution of mLVs, photoacoustic imaging and fluorescence imaging were used to observe and evaluate the structure and function of mLVs, and corresponding modulation strategy was developed to regulate mLV drainage for improvement of cognition and AD-associated pathology.
Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University