Long-Term Fluorescence Imaging Analysis and Targeted Detection of Eye Disease
Yao He
Suzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, China
Abstract
Fluorescein angiography (FA) is a standard imaging modality for evaluating vascular abnormalities in eye diseases, which is recognized as the major cause of vision loss. Long-term and real-time fluorescein angiography is of great importance in preclinical research, nevertheless remaining big challenges up to present. In this presentation, we show that long-term fluorescence imaging of vessels is enabled through a kind of fluorescent photostable probes, which feature strong fluorescence, robust photostability, lengthened blood residency and negligible toxicity. In particular, the presented nanoprobes are capable of imaging retinal capillaries in ~10 min, which is around 10-fold longer than that (~1 min) of fluorescein sodium (FS, known as the most widely used contrast agents for FA in clinic). On the other hand, based on rational surface modification of the probes, targeted fluorescence detection of neovascularization could be readily realized.
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Yao He
Soochow University
China
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