STUDY OF OSMOTIC AND CROSS-LINKING DEFORMATIONS IN BIOLOGICAL TISSUES BY OPTICAL COHERENCE ELASTOGRAPHY
Yu.A. Alexandrovskaya1,2, E.M. Kasianenko3, O.I. Baum3, A.A. Sovetsky1, A.L. Matveev1, T.A. Shmigol4, P.A. Karavaikin4,5, V.V. Negrebetsky4, V.Yu. Zaitsev1; 1A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia, 2Terra Quantum AG, Kornhausstrasse 25, CH-9000, St. Gallen, Switzerland, 3Institute of Photon Technologies, Federal Scientific Research Center “Crystallography and Photonics”, Russian Academy of Sciences, Troitsk, Moscow, Russia, 4N.I. Pirogov National Research Medical University, Ministry of Health of Russia, Moscow, Russia, 5Central Clinical Hospital with Polyclinic, Moscow, Russia
Abstract
The new insights into the diffusion-associated deformations of biological tissues studied by optical coherent elastography (OCE) are discussed in this study. The possible applications of the strain analysis to the diagnostics of the tissue early degradation, such as gradual proteoglycan depletion in cartilage, are proposed. It is shown that using the emerging OCE technique enabling quantitative visualization of spatially-resolved strain dynamics [1,2] the osmotically-induced deformations can be distinguished from the ones caused by the formation of collagen cross-links. The various chemical agents, such as organic alcohols, omnipaque, inorganic salts and glutaraldehyde, are considered in terms of their activity in inducing osmotic and cross-linking deformations in tissues and polyacrylamide gels (tissue phantoms) [3].
The study was supported by the Russian Science Foundation grant No. 22-12-00295
References
[1]. Alexandrovskaya, Y.; Baum, O.; Sovetsky, A.; Matveyev, A.; Matveev, L.; Sobol, E.; Zaitsev, V. Optical Coherence Elastography as a Tool for Studying Deformations in Biomaterials: Spatially-Resolved Osmotic Strain Dynamics in Cartilaginous Samples. Materials 2022, 15, 904.
https://doi.org/10.3390/ma15030904
[2] Yu. Alexandrovskaya, O. Baum, V. Zaitsev, A. Sovetsky, A. Matveyev, L. Matveev, K. Larin, E. Sobol, V. Tuchin, Optical and mechanical properties of the cartilage during optical clearing, In book Tissue optical clearing: new prospects in optical imaging, CRC Press (Dan Zhu, Elina Genina, and Valery Tuchin Eds.), 2021, Boca Raton, Florida, United States.
[3] Alexandrovskaya, Y.M.; Kasianenko, E.M.; Sovetsky, A.A.; Matveyev, A.L.; Zaitsev, V.Y. Spatio-Temporal Dynamics of Diffusion-Associated Deformations of Biological Tissues and Polyacrylamide Gels Observed with Optical Coherence Elastography. Materials 2023, 16, 2036.
https://doi.org/10.3390/ma16052036.
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Alexandrovskaya Yulia
Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia
Russia
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