CYTOTOXICITY OF SENNA DIDYMOBOTRYA LEAVES GREEN-SYNTHESIZED SILVER NANOPARTICLES AND PHOTOTHERAPY AGAINST A375 MELANOMA CELLS
MEHAK ZAHRA1, HEIDI ABRAHAMSE1, BLASSAN P. GEORGE 1*
Abstract
Cancer is a term used to describe a collection of illnesses where the cells within the body undergo unregulated growth and
multiplication. It is also worth noting that cancerous cells have the potential of entering the metastatic phase and this allows
them of invading adjacent body organs. Currently, there are at least five known conventional treatment modalities for
cancer treatment. However, these therapies have been reported of playing a significant role in the induction of tumor
recurrence. To address this critical issue, this study anti-proliferative effects of green synthesized silver nanoparticles
(AgNPs). The A375 melanoma cell line was employed as the experimental model, and a range of AgNPs concentrations
(2, 4, 8, 16 and 32 µg/mL) was applied. Subsequently, the treated cells were subjected to irradiation using a 525 nm diode
laser, at a light dose of 10 J/cm², and the morphological changes in cells were observed using a light inverted microscope.
Collectively, the results unveiled a dose-dependent reduction in cell proliferation in response to the AgNPs treatment.
Taken together, the findings from this study suggests that green-synthesized AgNPs poses significant therapeutic properties
as a novel therapeutic approach for the treatment of different forms of cancer, thus offering an effective and eco-friendly
therapeutic approach in cancer therapy.
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Speaker
Mehak Zahra
University of Johannesburg
South Africa
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