SYNTHESIS OF CATIONIC PORPHYRINS AND THEIR METAL COMPLEXES AS PHOTOSENSITIZING AGENTS FOR APDT
Inga O. Savelyeva, 1 Alexey U. Usanyov, 1 Kseniya A. Zhdanova, 1 Natalia A. Bragina, 1 Margarita A. Gradova, 2 Tatiana A. Shmigol, 3
1 MIREA- Russian Technological University, Moscow, Russia
2 Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia
3 Pirogov Russian National Research Medical University, Moscow, Russia
Abstract
The cationic derivatives of porphyrins are the objects of extensive research for using as photosensitizing agents for APDT. These compounds have positively charged structure which contributes to their active penetration in pathogens due to the non-covalent interactions with negatively charged components of fungi, bacteria cells and viral particles. Therefore, in this work a number of cationic meso-arylporphyrins and their complexes with Zn(II) with different numbers of nitrogen-containing heterocyclic groups at the periphery of the porphyrin macrocycle were synthesized as potential PSs for APDT. Photophysical, photochemical and aggregation properties of target cationic derivatives of porphyrins and their complexes with zinc were also studied. The antibacterial activity of the target compounds was investigated against suspensions and biofilms of bacteria S. aureus and E. coli.
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Savelyeva Inga Olegovna
MIREA- Russian Technological University
Russia
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