Effect of different nanoparticles on the parameters of pair red blood cells interaction in vitro: study by laser tweezers.
K.N. Korneev, D.A. Umerenkov, A.E. Lugovtsov, P.B. Ermolinskiy, A.V. Priezzhev
Faculty of Physics, M.V. Lomonosov Moscow State University, Moscow, Russia
Abstract
Nanoparticles (NPs) have strong potential for diagnostic and therapeutic applications in all industries, especially in medicine. Commonly it is intended to administer NP into human body by injecting them into the bloodstream. However, nowadays, there is no evidence confirming that this will not negatively influence the blood constitution and circulation and, consequently, the patient’s health. That is why it is important to characterize the RBCs interaction in the presence of NPs
In contrast to our previous works, in which the interaction of a certain type of NP, namely titanium dioxide, with RBC was studied, in this paper, the influence of different NPs on the characteristic time of RBCs pair aggregates (doublets) formation, the aggregation and disaggregation forces of RBCs was additionally studied using laser tweezers.
The obtained result show that the presence of any type of investigated nanoparticles in human blood leads to an increase in all measured parameters of RBC pair aggregation.
Based on our results, it can be concluded that incubation of nanoparticles with human blood results in a decrease of RBC aggregation rate. At the same time, the forces of aggregate formation and destruction become higher
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Speaker
Kirill Korneev
Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia
Russia
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