ASSESSMENT OF HAEMODYNAMIC PARAMETERS IN THE REHABILITATION PERIOD AFTER СOVID-19 USING WEARABLE BLOOD MICROCIRCULATION ANALYZERS
Ivan Yu. Vlasov,1 Elena V. Zharkikh,1 Yulia I. Loktionova,1 Elena V. Shuraeva,2 Andrey A. Fedorovich,3 Andrey V. Dunaev,1 1 Orel State University named after I.S. Turgenev, Orel, Russia 2 «Alsaria» Ltd., Orel, Russia 3 National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian Federation, Moscow, Russia
Abstract
The aim of this study was to compare blood microcirculation parameters in conditionally healthy volunteers and volunteers undergoing rehabilitation after COVID-19, and to assess the parameters of peripheral blood flow in dynamics after acute coronavirus infection to identify changes in the microcirculatory bed and further correction of rehabilitation measures. Wearable laser Doppler flowmeters "LAZMA-PF" (SPE "LAZMA" Ltd., Russia) were used in the study.
The study included two parts. The first part was conducted on two groups of volunteers: 13 conditionally healthy people, who had never been affected by COVID-19 and 23 people infected with COVID-19 previously.
The second study involved one male volunteer, aged 16 years, diagnosed with COVID-19. The volunteer had a concomitant disease, type 1 diabetes. Measurements have been taken for 10 days before the onset of coronavirus infection and for 26 days after recovery in the supine position for 10 minutes.
Both studies showed a tendency for the amplitudes of active blood flow oscillations to increase and that overall perfusion level decreases after the acute phase of coronavirus. It can be assumed that the recovery begins about 10 days after the onset of the disease and lasts more than a month, meanwhile the patients' body seeks to repair cells not by increasing arterial blood inflow but by redistributing it into the nutritive channel, gradually stabilizing the functioning of all systems.
Yu. I. Loktionova and A. V. Dunaev thank the Russian Foundation for Basic Research for financial support of research No. 20-08-01153 A and No. 19-29-14194 respectively.
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Ivan Vlasov
Orel State University named after I.S. Turgenev
Russia
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