Porphyrin conjugates with terpyridine moieties: complexation with metals and photodynamic activity
K.A. Zhdanova1, А.V. Ivantsova1, F.Yu. Vyal’ba1, M.A. Gradova2, N.Yu. Karpechenko3, N.A. Bragina1
1MIREA - Russian Technological University, Institute of Fine Chemical Technology, Moscow, Russia
2N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia
3N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Moscow, Russia
Abstract
Today, the development of diagnostic methods in oncology is one of the most promising approaches to combat these diseases. The development of multifunctional theranostic systems for combined diagnosis and therapy of cancer using photodynamic therapy (PDT) and MRI is a promising approach in clinical practice. Currently, non-specific contrast agents based on paramagnetic metals (Gd(III), Mn(II), Fe(III)) are used in clinical diagnostics. Porphyrin structures, despite their well-known coordination abilities, cannot provide sufficiently dense and stable binding to metal ions of large radius. In this regard, the introduction of an external chelating fragment into the molecular structure is necessary to realize the theranostic concept. The creation of tetrapyrrole conjugates with 4′-(4-methylphenyl)-2,2′:6′,2′′-terpyridine derivatives capable of coordinating metals regardless of their ionic radius is an important and relevant research in the diagnosis and treatment of malignancies. Conjugates of this type are promising research targets as potential theranostic agents.
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Zhdanova Kseniya
MIREA - Russian Technological University
Russia
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