Morphological Substantiation of Stiffness Changes of Breast Cancer Tissue During Neoadjuvant Therapy
Anton A. Plekhanov,1 Ekaterina V. Gubarkova,1 Marina A. Sirotkina,1 Vadim V. Elagin,1 Alexander A. Sovetsky,2 Dmitry A. Vorontsov, Alexandra Y. Bogomolova,1 Alexey Y. Vorontsov,3 Sergey V. Gamayunov,3 Vladimir Y. Zaitsev,2 and Natalia D. Gladkova,1
1 Privolzhsky Research Medical University, Nizhny Novgorod, Russia 2 Institute of Applied Physics RAS, Nizhny Novgorod, Russia 3 Nizhny Novgorod Regional Oncologic Hospital, Nizhny Novgorod, Russia
Abstract
In the presented study, we demonstrate patients' clinical cases with diagnosed breast cancer and prescribed neoadjuvant preoperative chemotherapy. We compared the elastic properties of tumor tissues taken by core needle biopsy before and during treatment. The studies were carried out using original home built multimodal optical coherence tomography system (IAP RAS, Russia) and multiphoton microscope (LSM 880, Carl Zeiss, Germany). Our research demonstrate to contribution of tumor cells and stromal fibers to the reduction of tumor stiffness during treatment.
The study was funded by the Russian Science Foundation, grant No. 18-75-10068.
Speaker
Anton Plekhanov
Privolzhsky Research Medical University
Russia
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