Topical influenza vaccine formulation based on vaterite particles
Yulia I. Svenskaya1, Ekaterina V. Lengert1, Yana V. Tarakanchikova2, Albert R. Muslimov3, Mariia S. Saveleva1, Elina A. Genina1, Igor L. Radchenko4, Liudmila A. Stepanova5, Andrey V. Vasin4, Gleb B. Sukhorukov6, Liudmila M. Tsybalova5
1Science Medical Center, Saratov State University, Saratov 410012, Russia
2Saint Petersburg Academic University, Saint-Petersburg 194021, Russia
3Sirius University of Science and Technology, Sochi 354340, Russia
4Peter the Great St. Petersburg Polytechnic University, Saint-Petersburg 195251, Russia
5Smorodintsev Research Institute of Influenza, Saint-Petersburg 197376, Russia
6Queen Mary University of London, London E1 4NS, United Kingdom
Abstract
Vaccination is one of the main methods for the prevention of infectious diseases. The search for non-invasive needle-free approaches towards the antigen delivery is of particular attention to meet the current challenges in the field. Transcutaneous immunization through the hair follicles represents one of the most promising strategies here due to recognition of the complex perifollicular network of immunoregulatory cells.
The reported study aimed to develop a novel bioinspired particulate system for topical influenza immunization enabling the avoidance of the stratum corneum disruption. Biodegradable vaterite carriers were utilized to transport the inactivated influenza vaccine into hair follicles. Effectiveness of the designed immunization protocol was demonstrated in animal model by means of micro-neutralization assay and ELISA. The results of our pilot study render the designed protocol of transfollicular immunization utilizing vaterite-based carriers a promising alternative to conventional invasive procedures.
The work is supported by Russian Science Foundation (project № 22-73-10194).
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Yulia Svenskaya
Saratov State University
Russia
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