Laser plasmon photothermal therapy of model tumors with optical clearing
Vadim D. Genin 1,2; Alla B. Bucharskaya 1,2,3; Georgy S. Terentyuk 1,3; Nikolai G. Khlebtsov 4; Nikita A. Navolokin 1,3; Valery V. Tuchin 1,2,5; Elina A. Genina 1,2; 1 - Saratov State University, Saratov, Russia; 2 - Tomsk State University, Tomsk, Russia; 3 - Saratov State Medical University, Saratov, Russia; 4 - Institute of Biochemistry and Physiology of Plants and Microorganisms RAS, Saratov, Russia; 5 - Institute of Precision Mechanics and Control RAS, Saratov, Russia.
Abstract
Currently, an urgent problem in medicine is the creation and development of new therapeutic technologies based on the use of nanoparticles for the treatment of oncological diseases. A subcutaneously transplanted cholangiocarcinoma in rats can serve an adequat tumor model for optimizing the method of plasmon photothermal therapy (PPT). The developed method of laser PPT of tumors includes two stages. At the first stage, an optically clearing agent is applied to the skin surface over the tumor after intratumoral administration of a suspension of gold nanorods and low intensity IR laser irradiation is performed. At this time, due to the diffusion of glycerol into the skin tissue, the skin becames more transparent, and the depth of light penetration increases. At the second stage, the laser radiation power is increased for realizing effect of thermal damage of tumor. The use of optical clearing technique helps to reduce skin damage during hyperthermia. The study was supported by the RFBR grant, no. 20-52-56005.
Speaker
Vadim D. Genin
Saratov State University
Russia
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