Wearable fNIRS on studies of neurohydrodynamics
Teemu Myllylä,1,2*, Sadegh Moradi,2, Martti Ilvesmäki,1, Vesa Korhonen,1, Hany Ferdinando,1, Vesa Kiviniemi,1
1 University of Oulu, Research Unit of Health Sciences and Technology, Oulu, Finland
2 University of Oulu, Optoelectronics and Measurement Techniques Unit, Oulu, Finland
Abstract
There is increasing interest among brain researchers and clinicians in neurohydrodynamics and their mechanisms, as regards studies of the glymphatic system and brain clearance in relation to neurodegeneration diseases. Functional near-infrared spectroscopy (fNIRS) is commonly used for measuring cerebral hemodynamics. This presentation discusses potential of the presented wearable fNIRS technique for measuring neurohydrodynamics. In particular, we study the interaction between cerebral circulation and cerebrospinal fluid (CSF) in human with special interest in neurovascular-CSF coupling. Our results gathered with wearable fNIRS show the neurovascular-CSF coupling effect and their interaction is in consistent with the Munro–Kellie doctrine, which states that the intracranial sum of the volumes of brain matter, CSF, and blood must be constant. The presented wearable technique is currently used in several study cases which are also introduced.
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Teemu Myllylä
University of Oulu
Finland
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