Study of the cytotoxic properties of polyester-based copolymers for the bioresorbable triboelectric nanogenerator (TENG) development
V. V Deeva, N. I. Kazachkina, V. V. Zherdeva
Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences. 33, bld. 2 Leninsky Ave., Moscow 119071, Russia
Abstract
The aim of our work was to study the potential cytotoxicity of polyester copolymers as the basis of an implantable, bioresorbable TENG nanogenerator.
Four samples of polyester copolymers of the total composition: citrate(a)-hexanediol(b)-propane-1,2-diol(c)-glutarate(d) (CHPG) of various degrees of cross-linking (no.1-4 in order of increase of condensation) were investigated for their potential applicability for TENG. Three cell lines of murine origin were used to study cytotoxicity: A9 fibroblast-like cells, C2C12 myoblast-like cells, J774 histiocytic sarcoma. Cell viability was estimated using a colorimetric test for the metabolic activity of cells (MTT-test).
It was shown that the cytotoxicity of the studied polymers correlated with the total amount of the copolymers samples, but not the surface square of the copolymer disks. That reveals the main role of the hydration of the samples. The manifestation of cytotoxic properties was not confirmed under the condition of 100% confluence of cultures, except for samples with a low degree of polycondensation (CHPG-1 and CHPG-2) at high concentrations (0.05-0.07 mg).Thus, CHPG polyester copolymers were decided promising for use in TENG.
The work was supported by the grant of Ministry of Science and Higher Education of the Russian Federation no. 13.2251.21.0009 (Agreement no. 075-15-2021-942).
Speaker
Viktoria Deeva
Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences. 33, bld. 2 Leninsky Ave., Moscow 119071
Russia
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