Сhallenges and prospects оf combined laser therapy in oncology
Alla Bucharskaya1,2,4, Gаlina Maslyakova1,2, Nikita Navolokin1,2, Georgy Terentyuk2, Nikolai Khlebtsov2.,3, Boris Khlebtsov3, Vadim Genin2,4, Elina Genina2,4, Valery Tuchin2
1 Saratov State Medical University, Saratov, Russia
2 Saratov State University, Saratov, Russia, 410012
3 Institute of Biochemistry and Physiology of Plants and Microorganisms of Federal Research Center "Saratov Scientific Center of the Russian Academy of Sciences", Saratov, Russia
4 National Research Tomsk State University, Tomsk, Russia
Abstract
Despite significant progress in the treatment of cancer, the effectiveness of standard chemotherapy and radiation therapy for the treatment of a number of malignant neoplasms remains insufficient, which may be due in part to the development of resistance to drugs in tumor cells and the pronounced toxicity of chemotherapy and radiation therapy. An important trend in the development of experimental and clinical oncology is the transition to complex treatment of tumors using combined therapeutic strategies. The rapid development of nanotechnology makes it possible to create fundamentally new approaches to cancer treatment, as well as to optimize existing ones. Despite the long history of laser hyperthermia as a treatment method in oncology, the low selectivity of laser heating, which causes damage to the tissues surrounding the tumor, limits its use. The use of nanothermosensitizers, including plasmon resonance gold nanoparticles, allows increasing selective damage of tumor tissue with decreasing toxic effect on healthy tissues. Photodynamic therapy based on the use of photosensitizers and laser radiation is a promising method of tumor therapy. The report is devoted to the challenges and prospects of combined laser technologies of antitumor therapy.
Speaker
Alla Bucharskaya
Saratov State Medivcal University
Russia
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