Colocalization of repetitive proton wire patterns with transcription starts supports the DNA resonance hypothesis
Ivan Savelev, 1, Lev Shishkin, 1, Liliya Yulmetova, 1, Oksana Polesskaya, 2, Alexander Vetcher, 1,3,4, Richard Alan Miller, 5, Max Myakishev-Rempel, 1
1 - DNA Resonance Research Foundation, San Diego, CA, USA
2 - University of California, San Diego, USA
3 - Nanotechnology Scientific and Educational Center, Institute of Biochemical Technology and Nanotechnology, Peoples Friendship University of Russia, Moscow, Russian Federation
4 - Shishonin Complementary and Integrative Health Clinic, Moscow, Russian Federation
5 - OAK, Inc., Grants Pass, OR, USA
Abstract
The concept of electromagnetic signaling in biological tissues has been around almost since Hertz's experiment proving the existence of electromagnetic waves. Although electromagnetic signaling would better explain the speed and precision of the work of the genome and coordination between the cells than chemical signaling, molecular mechanisms and experimental evidence for it are insufficient. Previously, we proposed that DNA, being the central program of life and a very stable substance, is directly involved in electromagnetic signaling and that its sequences harbor sequence-dependent electromagnetic oscillators. We also proposed two types of sequence-dependent electromagnetic oscillation - the ones that include delocalized negative and positive charges. The first type is proposed to occur in purine stretches in DNA, i.e. stacks of purine bases A and G with electrons delocalized across stacked aromatic rings. The second type consists of proton wires, that is chains of hydrogen bonds connecting polar groups of sequential nucleobases in the base stack. Previously we demonstrated that patterns of these proton wires can be deduced from the DNA sequence and that specific patterns of proton wires are strongly enriched by the evolution in the genome and enriched in evolutionarily conserved sequences. Here we demonstrate that repetitive proton wire patterns are enriched around gene transcription starts thus providing additional evidence for the DNA resonance signaling hypothesis.
Speaker
Max Myakishev-Rempel
DRRF
USA
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