А model of norepinephrine influence on nervous system activity

Abstract

The normal functioning of the central nervous system of any living organism is possible only if there is a stable and adaptive blood supply. The circulatory system delivers oxygen and nutrients to the brain, providing energy homeostasis. On the one hand, neuronal activity leads to the synthesis of nitric oxide in neurons, which directly affects the smooth muscle cells of blood vessels, causing their dilation. On the other hand, signaling between neurons and astrocytes operates through neurogliotransmitter interaction. Neurogliotransmitter coupling in conjunction with norepinephrine signaling, which acts as a cognition-related neuromodulator by affecting neuronal excitability and synaptic efficacy at both presynaptic and postsynaptic levels, play an important role in the control of synaptic signals and plasticity of glial cells. To date there are many open questions related to the effect of norepinephrine on astroglia in the context of an indirect effect on synaptic activity. We built a mathematical model that takes into account the initial effect of norepinephrine on the calcium activity of the astrocyte and the further indirect effect on synaptic activity. It has been shown that the addition of external norepinephrine regulation significantly change calcium activity, which makes it reasonable to incorporate into the model conception the results of recent experimental studies on norepinephrine as a key player in the functioning of the brain. This study was supported by the Russian Science Foundation, grant 22-74-00146.

Speaker

Pavel O. Lukin
Kursk State University
Russia

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