Experimental Setup based on Infrared quantum-cascade laser spectroscopy for analysis of microcomponents in human exhaled breath
Olga A. Nebritova, 1
Igor L. Fufurin, 1
Artem A. Esakov, 1
Andrey N. Morozov, 1
Bauman Moscow State Technical University, Moscow, Russia
Abstract
Exhaled breath analysis containing more than a thousand volatile organic compounds (VOC) biomarkers that can be capable of non-invasive diagnosis of diseases at the point of care. Even though the relationship of the VOCs with pathologies has been well studied, the diagnosis of exhaled breath remains analytically and practically a difficult task. This is related to the concentration level in ppb and sub-ppb. The infrared quantum cascade laser spectroscopy allows to measure number of VOCs in human breath with high selectivity and sensitivity. We designed an experimental setup for the analysis of human exhaled breath and the protocol of the medical tests. Experimental setup consists of a quantum cascade laser with a tuning range of 5.3–12.8 µm, peak power up to 150 mW and Herriot astigmatic gas cell with optical path up to 76 m. Designed experimental setup and protocol allows in situ to detect a human disease or pathology in the human body.
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Olga A. Nebritova
Bauman Moscow State Technical University, Moscow, Russia
Russia
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