Analysis of biomarkers concentrations in human exhaled breath for the primary diagnosis of type 1 diabetes mellitus
Anastasiya V. Scherbakova, 1
Pavel V. Berezhanskiy, 2
Igor S. Golyak, 1
Dmitriy R. Anfimov, 1,
Pavel P. Demkin, 1
Olga A. Nebritova, 1
Andrey N. Morozov, 1
Igor L. Fufurin, 1
1 Bauman Moscow State Technical University, Moscow, Russia
2 Morozov Children’s Clinical Hospital, State Budgetary Healthcare Institution, Moscow Healthcare Pulmonology Department, Moscow, Russia
Abstract
In this paper, methods for analyzing concentrations of biomarkers in human exhaled breath for the primary diagnosis of several diseases are considered. An experimental setup for determining the quantitative and qualitative composition of the gas mixrture is presented. We use quantum cascade laser emitting in a pulsed mode with a peak power of up to 150 mW in the spectral range of 5.3–12.8 μm and Herriot multipass gas cell with an optical path length of 76 m. The method for analysis of exhaled human breath for the diagnosis of type 1 diabetes mellitus is presented. We examine acetone, ethanol and isopropanol as biomarkes for type 1 diabetes mellitus. As a result of the study, a significant excess of acetone and ethanol content in exhaled air was shown in volunteers with confirmed type 1 diabetes mellitus. The proposed method can be supplemented with methods based on neural networks, which will give the most accurate diagnosis of the disease.
Speaker
Anastasiya V. Scherbakova
Bauman Moscow State Technical University
Russia
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