Raman spectroscopy and chemometrics for the detection of chronic heart disease and kidney failure
Yulia A. Khristoforova, Samara University, Russia
Ivan A. Bratchenko, Samara University, Russia
Lyudmila A. Bratchenko, Samara University, Russia
Petr A. Lebedev, Samara State Medical University, Russia
Maria A. Skuratova, Samara City Clinical Hospital №1 named N.I. Pirogova, Russia
Elena A. Lebedeva, Samara City Clinical Hospital №1 named N.I. Pirogova, Russia
Valery P. Zakharov, Samara University, Russia
Abstract
Inflammatory and degenerative processes in the heart and kidneys lead to physiological and pathological changes in the chemical composition of biological tissues and biofluids due to metabolic disorders in the human body. The structural changes in the functional groups of nucleic acids, proteins, lipids and carbohydrates are most important biomarkers of non-infectious diseases. The human skin is accessible and therefore attractive as an in vivo diagnosis object for detection of biochemical changes. In this study, nearly 200 skin Raman spectra of patients with chronic heart disease and kidney failure and 80 skin Raman spectra of healthy volunteers were registered. In vivo study was performed using Raman portable setup that includes laser diode with 785 nm central wavelength with 80 mW output laser power, QE65Pro spectrometer, inPhotonics optical probe. The major registered Raman band are associated with υ
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Yulia Khristoforova
Samara National Research University
Russian Federation
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