Study of the Precancerous Lesions Early Detection Possibility in the Oral Mucosa in vivo using Diffuse Reflectance Spectroscopy
Alexander V. Kolpakov,1 Ekaterina V. Melikhova,1 Natalya P. Muravskaya,1 Andrey V. Samorodov,1 Nina O. Kopaneva,2 Galina I. Lukina, 2 Marina Ya. Abramova, 2
1Bauman Moscow State Technical University, Moscow, Russia
2 Moscow State University of Medicine and Dentistry, Moscow, Russia
Abstract
This report is devoted to the experimental validation of the precancerous lesions early detection possibility in the Oral Mucosa in vivo using diffuse reflectance spectroscopy in the wavelength range from 360 to 1000 nm. In the course of the study the sample of 18 patients with hyperkeratosis has been collected and analyzed. As a results of the analysis the most informative wavelength ranges were determined, in which the maximum differences in the backscattering spectra of lesions and intact tissues were observed, methods for automatic classification of backscattering spectra of the oral mucosa were studied, sensitivity and specificity values, achievable using diffuse reflectance spectroscopy for detecting hyperkeratosis on the tongue ventrolateral mucosa surface and buccal mucosa, were evaluated. As a result of preliminary experimental studies in vivo, the possibility of automatic detection hyperkeratosis areas on the tongue ventrolateral mucosa surface using diffuse reflectance spectroscopy in the wavelength ranges from 450 to 650 nm and from 750 to 1000 nm, also as the possibility of automatic detection hyperkeratosis areas on the on the buccal mucosa surface using diffuse reflectance spectroscopy in the wavelength ranges from 450 to 830 nm and from 870 to 1000 nm has been shown.
Speaker
Alexander V. Kolpakov
Bauman Moscow State Technical University
Russia
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