Experimental study of ozone-photodynamic effects in malignant growth
Evgeniya S. Zhukova,1 Tatiana G. Scherbatyuk,1,2,3 Andrew B. Gapeyev,2,4
1 Nizhny Novgorod research institute for hygiene and occupational pathology, Nizhny Novgorod, Russia; 2 Moscow Region State University, Mytishchi, Moscow Region, Russia; 3 Pushchino State Institute of Natural Science, Pushchino, Russia; 4 Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino, Moscow Region, Russia
Abstract
Photodynamic therapy is a relatively gentle and developing method of treatment in oncology, the mechanism of which action is based on the generation of reactive oxygen species. However, hypoxic states of tumors reduce the therapeutic efficacy of photodynamic effects. One of the ways to overcome tissue hypoxia is an ozone therapy. In the study, we have developed an experimental-therapeutic scheme for the combined use of photodynamic effects and medical ozone and assessed its efficacy in the growth of PA carcinoma.
The study was supported by the Russian Foundation for Basic Research (project No. 19-02-00667).
Speaker
Evgeniya Sergeevna Zhukova
Nizhny Novgorod research institute for hygiene and occupational pathology, Nizhny Novgorod
Russia
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