Application of dynamic light scattering method in studies of porphyrazine and phthalocyanine photosensitizers
A.R. Krot, I.A. Sergeeva, K.V. Fedorova
Department of molecular processes and extreme states of matter, Faculty of Physics, Lomonosov Moscow State University, Moscow 119991, Russia
Abstract
The complexes of nanoparticles — promising photosensitizers that are used for diagnostics and photodynamic therapy of oncological diseases, were synthesized by the combination of inorganic nanostructures with polymerization of organic monomer method based on porphyrazines and phthalocyanines of aluminum, magnesium, zinc and polyvinylpyrrolidone as a polymer. As a result of the circulation of nanoparticles in the bloodstream, they passively accumulate in the tumor tissues due to the EPR effect. One of the key conditions for observing this effect is the particle size, which in most cases should not exceed 200 nm. The dynamic light scattering method was used to determine for the first time the values of the hydrodynamic radii of biocompatible micellar forms and the most stable complexes of these nanoparticles were established. The tendency to increase the size of the photosensitizer with an increase in the relative concentration of the polymer is revealed, which makes it possible to form a well-established technology for the synthesis of nanoparticles of the required size, to implement targeted delivery to tumor tissues using the ≪passive targeting≫ method.
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Aleksey Romanovich Krot
Faculty of Physics, Lomonosov Moscow State University
Russia
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