Deformation response of biological phantoms and cartilage tissue under laser exposure

Abstract

Regeneration of cartilage tissue and changes in its shape under laser exposure are promising medical operations that improve the patient's quality of life. The most important criterion for the success of such operations is cell survival after laser exposure; therefore, reducing the duration and power of exposure is an important task for the development of such techniques.
Nanoparticles are actively used in medicine, and one of the niches of their use is the enhancement of the photothermal effect upon laser action on tissues. However, the articular tissue is quite resistant to the penetration of foreign agents into it; therefore, the study of the penetrating ability of nanoparticles and the effect of their impregnation is an advanced task in improving operations.
In this work, we investigated the photothermal effect of metal oxide bronzes and magnetite nanoparticles when heated by an Er-fiber laser of cartilaginous articular tissue and gel phantoms. Optical coherent elastography of gel phantoms with dissolved nanoparticles was carried out.
Sections of articular cartilage tissue of four types (intact, with mechanical damage, with laser damage and after weak laser exposure) were impregnated with NaхTiO2 and Fe3O4 nanoparticles, for further study on OCT. An increase in deformations caused by heating of phantoms and tissues impregnated with nanoparticles was found; OCT data indicate the dependence of tissue deformations on the previous effect on the tissue.
The work proves the effectiveness of increasing the photothermal effect of laser radiation on tissue deformation with the introduction of various nanoparticles.

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Speaker

Ekaterina Kasianenko
Institute of Photon Technologies, Federal Scientific Research Center “Crystallography and Photonics”, Russian Academy of Sciences, Troitsk, Moscow, Russia
Russia

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