Topical antifungal formulation for the treatment of dermatophyte infections
Yulia Svenskaya, Sararov State University, Russia
Ekaterina Lengert, Sararov State University, Russia
Mariia Saveleva, Sararov State University, Russia
Roman Verkhovskii, Sararov State University, Russia
Georgy Terentyuk, Sararov State University, Russia
Elina Genina, Sararov State University, Russia
Valery Tuchin, Sararov State University, Russia.
Abstract
Topical therapy of superficial fungal infections allows the prevention of systemic side effects and provides drug targeting at the site of disease. However, an appropriate drug concentration in these sites should be provided to ensure the efficacy of such local treatment. The enhancement of intra- and transdermal penetration and accumulation of antifungal drugs is an important aspect here. Here report on a novel approach for topical antifungal treatment based on addressing of drug-loaded submicron vaterite particles into the deep layers of the skin through the hair follicles. The particles were demonstrated to be capable of providing a high antimycotic loading capacity and a long-term release of the payload. High efficiency of the cellular uptake together with extremely low cytotoxicity were demonstrated. A prolonged antifungal drug release ensured the enhanced therapeutic effect of the proposed system in vivo.
The study was supported by Russian Science Foundation (project № 17-73-20172).
Speaker
Yulia Svenskaya
Saratov State University
Russia
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