Scaffolds of WPI hydrogels with prolonged release of drugs for antimicrobial therapy

Abstract

The practice of systemic antibiotic therapy used in maxillofacial surgery and bone implantation is not always effective due to poor blood supply to the infected area and increased bacterial resistance to antibiotics. In recent years, biologically active antibacterial scaffolds have been introduced, which are analogs of the extracellular matrix, allowing to regenerate and restore the functions of tissues and organs. The article presents hydrogel scaffolds based on a natural whey protein (WPI) with a broad-spectrum antibiotic. During the experiments carried out in the presented work, it was proved that the highly hydrated three-dimensional polymer structure of the investigated hydrogels allows them to be used as a targeted drug delivery system due to the prolonged release of drugs in the region of interest. This approach reduces stress and side effects on healthy organs while increasing the therapeutic effect in the area of interest.
This work was supported by the Russian Science foundation (project no. 21-75-10042).

Speaker

Valentina O. Plastun
Saratov State University
Russia

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