Structured biomaterials for prolonged and controlled release of antibiotics and anti-inflammatory drugs from the surface of implants

Abstract

Perimplant infections and hypertrophied growth of connective tissue are the main side effects associated with implantation. In this regard, creating coatings capable of prolonged release of antibiotics and anti-inflammatory drugs is an urgent task. However, it should be borne in mind that every patient's adverse reaction to the implant does not develop in the same way. In some cases, the intake of the drug in small doses is sufficient; in others, a sharp, one-time discharge of a significant amount of the encapsulated drug is required. This is especially true in the case of a strong bacterial infection when it is necessary to quickly create a high local concentration of the antibiotic directly in the focus of infection. Structured films with microchamber arrays are a promising new material that can provide a prolonged, uniform release over the entire surface of the implant. At the same time, this biomaterial is sensitive to the action of both therapeutic and diagnostic ultrasound. The inclusion of photoadsorbing agents (for instance, gold nanoparticles, aggregates of carbon dots) into the shells of microcontainers also makes it possible to stimulate release using laser radiation in both the visible and IR ranges. Thus, films with microcontainer arrays are a good candidate for personalized traumatology and regenerative medicine.

The bacteriological and controlled release studies were supported by Russian Science Foundation (project no 21-75-10042). Olga A. Sindeeva acknowledges the Grant of the President of the Russian Federation (МК-4273.2021.1.4) for supporting the experimental part of the work related to characterization samples by SEM and CLSM.


File with abstract

Speaker

Ekaterina Prikhozhdenko
Saratov State University
Russian Federation

Discussion

Ask question