Investigation of magnetic polyelectrolyte microcapsules’ behavior in mouse blood
Authors:
Roman Verkhovskii1, Alexey Ermakov1,2, Olga Sindeeva3, Daniil Bratashov1
Affiliations:
1 - Science Medical Center, Saratov State University, 83 Astrakhanskaya str., Saratov, 410012 Russia
2 - I. M. Sechenov First Moscow State Medical University, Moscow, Russia
3 - Skolkovo Institute of Science and Technology, 3 Nobelya st., Moscow 121205, Russia
Abstract
Drug carriers remotely controlled with an external source of magnetic fields are a promising drug delivery system that decreases drugs’ side effects by targeting them to the lesion area. However, peculiarities of the microcapsules’ behavior in vivo are under controversy. Here, we discuss processes occurring in the blood flow, such as circulation time of magnetic polyelectrolyte microcapsules in mouse blood after injection in the tail vein. Investigation of microcapsules ranging in diameter 1-5.5 um allowed us to reveal the dynamics of the microcapsules’ filtration by vital organs dependent on the size of microcapsules. Then we consider such parameters as cytotoxicity and hemotoxicity of magnetic polyelectrolyte capsules. Our results demonstrate that capsules of the small size do not obstruct blood cells, while large 5.5 um microcapsules induce inhibition of cell line proliferation after 48h and cause the increase in hemolysis depending on the carrier concentration.
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Speaker
Roman Verkhovskii
Science Medical Center, Saratov State University
Россия
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