Calcium carbonate-based protein-tannin carriers with cytostatic activity
Anatolii A. Abalymov,1 Polina A. Demina,1 Denis V. Voronin,1,2 Alexandr V. Sadovnikov1 and Maria V. Lomova,1
1 Saratov State University, Astrakhanskaya St. 83, Saratov 410012, Russia,
2 National University of Oil and Gas “Gubkin University”, Leninsky Prospekt 65, Moscow 119991, Russia
Abstract
Hybrid nanostructured materials are vell tunable and controllable carriers for anticancer drug delivery. Calcium carbonate-based highly-magnetic protein-tannin carriers can be very useful for these goals due to their specific properties and unique architecture. The saturation level of submicron particles of calcium carbonate with magnetic nanoparticles was achieved. The Brillouin light scattering method and the determination of the motion of composites in an inhomogeneous magnetic field, as well as the study of hybrid mineral high-magnetic composites using SEM, made it possible to characterize the magnetic properties of the carriers and determine that 3 freezing/thawing cycles of magnetic nanoparticles are sufficient to obtain an optimal drug carrier. We have demonstrated that mitoxantrone and doxorubicin have a high level of conjugation to hybrid particles. These anti-cancer hybrid structures were tested for the determination of cytostatic activity on MCF-3 and NMUMG cell lines and show that anticancer activity is the same with free drug, but minimal release and possibility of concentration the carriers by magnetic field make the perspective of the particle for future clinical application.
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Anatolii Abalymov
Saratov State University
Russia
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