The impact of 755 and 1064 nm laser radiation on murine melanoma and macrophage cell line
Authors: Anatolii Abalymov1, Roman Verkhovskii1, Oleg Grishin1, Olga Inozemtseva1
Affiliations: 1 - Laboratory of Biomedical Photoacoustics, Science Medical Center, Saratov State University
Abstract
One of the main problems in treating oncological diseases is their spreading in the body through metastasis. Therefore, the development of new approaches to non-invasive prevention and treatment of metastatic diseases is an urgent task of modern medicine. The most promising approach is the application of physical non-invasive methods for the destruction of circulating tumor cells (CTCs), which are the "seeds" for further metastasis' formation. The cells of cutaneous malignant melanoma have melanin granules within them, which are a well-absorbing target for photoacoustic (PA) detection and photothermal (PT) destruction. In this work, we have demonstrated the effect of 755 and 1064 nm lasers on the survival of melanoma and macrophage cells in flowing conditions. Obtained data demonstrate a significant decrease in B16F10 cell viability without harming normal cells.
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Anatolii Abalymov
Saratov State University
Бельгия
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